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FLASH GENE
Symbol CHST15 contributors: np/ - updated : 14-05-2008
HGNC name carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
HGNC id 18137
Location 10q26.13      Physical location : 125.767.185 - 125.806.241
Synonym name
  • B cell RAG associated protein
  • N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
  • Synonym symbol(s) BRAG, KIAA0598, MGC34346, RP11-47G11.1, DKFZp781H1369, GALNAC4S-6ST, GALNAC4S6ST
    EC.number 2.8.2.33
    DNA
    TYPE functioning gene
    STRUCTURE 39.06 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4713 64.9 561 - PMID: 16024005
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
     bone marrow  highly
    Connectivebone   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the N-terminal 81 -AA in the cytoplasm
  • a 17-AA transmembrane domain
  • a C-terminal 405-aa extracellular domain
  • four potential N-glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila trn
    Homologene
    FAMILY
  • type II transmembrane glycoprotein family
  • sulfotransferase 1 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO4)repeating units
  • regulating RAG expression
  • biosynthesis of chondroitin and dermatan sulfate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    endometrial cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS