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FLASH GENE
Symbol TAF10 contributors: npt/ - updated : 17-05-2006
HGNC name TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
HGNC id 11543
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Digestiveliver   highly
Endocrinepancreas   highly
Lymphoid/Immunelymph node    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • TAF2H family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text cytoplasmic-nuclear transport of TAF10 is naturally observed during the differentiation of adult male germ cells (Soutoglou 2005)
    basic FUNCTION
  • involved in transcription complex assembly and regulation necessary for transcriptional activation by the estrogen receptor
  • with SUPT7L-TAF8 and also the SMAT complex, seem to be important regulators of the composition of different TBP and/or STAGA/TFTC complexes in the nucleus and consequently may play a role in gene regulation (Demeny 2007)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • three histone fold-containing interaction partners: TAF3, TAF8, and SUPT7L (Soutoglou 2005)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS