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FLASH GENE

Symbol

TAF10

contributors: npt/ - updated : 17-05-2006

HGNC name	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
HGNC id	11543

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE
text	overlapping the ILK transcript at its 3'end
STRUCTURE	1.37 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map

see CLN2

regionally located

physically adjacent to LPPI (CLN2)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006284 5 - 762 NP_006275 - 218 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Digestive liver       highly Endocrine pancreas       highly Lymphoid/Immune lymph node         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

spleen

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

TAF2H family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	cytoplasmic-nuclear transport of TAF10 is naturally observed during the differentiation of adult male germ cells (Soutoglou 2005)

basic FUNCTION	involved in transcription complex assembly and regulation necessary for transcriptional activation by the estrogen receptor
	with SUPT7L-TAF8 and also the SMAT complex, seem to be important regulators of the composition of different TBP and/or STAGA/TFTC complexes in the nucleus and consequently may play a role in gene regulation (Demeny 2007)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	TATA box binding (TBP)
	three histone fold-containing interaction partners: TAF3, TAF8, and SUPT7L (Soutoglou 2005)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS