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FLASH GENE
Symbol SLC24A3 contributors: mct - updated : 10-09-2009
HGNC name solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
HGNC id 10977
EXPRESSION
Rna function highly in brain, smooth muscle, uterus, aorta, intestine
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselsaorta   
Nervousbraindiencephalonthalamusnucleihighly
 braindiencephalonhypothalamus highly
Reproductivemale systemprostate  moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothvessel highly
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two large hydrophilic loops
  • two sets of transmembrane spanning segments (TMs)
  • the first large hydrophilic loop is located extracellularly at the N-terminus
  • the other is cytoplasmic and separates the two sets of TMs
  • HOMOLOGY
    intraspecies homolog to NCKX1
    homolog to NCKX2
    Homologene
    FAMILY
  • sodium/potassium/calcium exchanger family
  • SLC24A subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • K dependent (Na+) (Ca2+) exchanger regulating intracellular Ca2+ concentration
  • polytopic membrane protein that plays a critical role in Ca(2+) homeostasis in retinal rod and cone photoreceptors
  • playing a role in mediating agonist-stimulated [Ca2+]cyt and thereby vascular tone
  • probably play a particularly prominent role in regulating Ca2+ flux in environments which experience wide and frequent fluctuations in Na+ concentration
  • plays a critical role in the transport of an intracellular calcium and potassium ion in exchange for four extracellular sodium ions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS