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FLASH GENE
Symbol ERGIC2 contributors: mct/npt - updated : 30-06-2010
HGNC name ERGIC and golgi 2
HGNC id 30208
Location 12p11.22      Physical location : 29.493.579 - 29.534.143
Synonym name
  • prostate nuclear gene
  • endoplasmic reticulum-Golgi intermediate compartment protein 2
  • PTX1-like protein
    • Synonym symbol(s) PSTX1, CDA14, Erv41, MGC111152, cd002, PTX1, ERGIC32
    DNA
    TYPE functioning gene
    STRUCTURE 40.56 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1781 45 377 - Kwok (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineparathyroid   highly
    Lymphoid/Immunethymus    
    Reproductivemale systemprostate  highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast Erv41p
    ortholog to murine 1200009B18Rik
    homolog to zebrafish zgc64005
    Homologene
    FAMILY
  • ERGIC family
    • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text in the nuclei of glandular epithelia of prostate
    basic FUNCTION
  • playing an important role in the growth and tumorigenicity of PC-3 prostate tumor cells
  • involved in protein trafficking between ER and Golgi
  • involved in protein transportation, and participated in the elongation factor 1 alpha regulated mechanisms (Yang 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ERGIC2-ERGIC3 complex involved in transport between the endoplasmic reticulum and Golgi complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate carcinoma (see TSG12B)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS