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FLASH GENE
Symbol DUSP22 contributors: - updated : 18-03-2006
HGNC name dual specificity phosphatase 22
HGNC id 16077
Location 6p24.3      Physical location : 292.100 - 351.353
Synonym name
  • JNK-stimulating phosphatase 1
  • mitogen-activated protein kinase phosphatase X
  • homolog of mouse dual specificity phosphatase LMW-DSP2
  • VHR-related MKPX (VHX)
    • Synonym symbol(s) JSP1, LMW-DSP2, MKPX
    DNA
    TYPE functioning gene
    STRUCTURE 59.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Endocrinepancreas    
    Reproductivemale systemtestis   
    Respiratorylung    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connective    
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		one single DSP catalytic domain
    HOMOLOGY
    interspecies homolog to murine Lmw-dsp2
    intraspecies homolog to DUSP15
    Homologene
    FAMILY mitogen-activated protein kinase phosphatase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION may be dephosphorylating and inactivating MAP kinases
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to P38 and SAPK (dephosphorylation and deactivaction)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS