Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ITLN1

contributors: mct/npt - updated : 04-10-2012

HGNC name	intelectin 1 (galactofuranose binding)
HGNC id	18259

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   associated with increasing obesity and insulin resistance constitutional     --low   by insulin and glucose (explain the decreased omentin-1 levels observed in overweight women with PCOS (Tan 2008) constitutional     --low   decreases in the overweight and obese human subjects constitutional     --low   found in many chronic inflammatory diseases constitutional     --low   in patients with acute coronary syndrome (ACS) and stable angina pectoris compared with controls constitutional     --over   SERPINA12 and ITLN1 are up-regulated in large for gestational age infants at term

Susceptibility

to obesity with insulin resistance

Variant & Polymorphism SNP	single nucleotide missense polymorphism Val109Asp associated with type 2 diabetes mellitus or chronic inflammatory bowel diseases

Candidate gene	omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity
Marker
Therapy target
	System Type Disorder Pubmed diabete     may be a potential drug target against the obesity and/or type II diabetes-related vascular diseases

ANIMAL & CELL MODELS