Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ITLN1

contributors: mct/npt - updated : 04-10-2012

HGNC name	intelectin 1 (galactofuranose binding)
HGNC id	18259

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , trimer

HOMOLOGY

interspecies

homolog to murine intelectin

Homologene

FAMILY

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	brush border membrane

basic FUNCTION	adipokine playing a role in the recognition of bacteria-specific components in the host
	adipokine expressed in omental adipose tissue in humans and may regulate insulin action
	adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease
	its loss may contribute to the development of insulin resistance and T2DM
	potent insulin-sensitizing adipokine, and serum omentin levels possibly play an important role in the pathogenesis of insulin resistance and diabetes
	adipocytokine with insulin-sensitizing effect
	plays an anti-inflammatory role by preventing the TNF1-induced COX2 expression in vascular endothelial cells
	anti-inflammatory in vascular endothelial cells
	may inhibit TNF-induced expression of adhesion molecules in endothelial cells via blocking ERK/NFKB1 pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	omentin inhibited TNF-activated signal pathway of NFKB1 by preventing NFKB1 inhibitory protein (NFKBIA) degradation and NFKB1/DNA binding activity
	ITLN1 inhibition of TNF-induced expression of VCAM1 and ICAM1 is mediated by its down-regulation of ERK/NFKB signaling pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   associated with increasing obesity and insulin resistance constitutional     --low   by insulin and glucose (explain the decreased omentin-1 levels observed in overweight women with PCOS (Tan 2008) constitutional     --low   decreases in the overweight and obese human subjects constitutional     --low   found in many chronic inflammatory diseases constitutional     --low   in patients with acute coronary syndrome (ACS) and stable angina pectoris compared with controls constitutional     --over   SERPINA12 and ITLN1 are up-regulated in large for gestational age infants at term

Susceptibility

to obesity with insulin resistance

Variant & Polymorphism SNP	single nucleotide missense polymorphism Val109Asp associated with type 2 diabetes mellitus or chronic inflammatory bowel diseases

Candidate gene	omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity
Marker
Therapy target
	System Type Disorder Pubmed diabete     may be a potential drug target against the obesity and/or type II diabetes-related vascular diseases

ANIMAL & CELL MODELS