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FLASH GENE

Symbol

ITLN1

contributors: mct/npt - updated : 04-10-2012

HGNC name	intelectin 1 (galactofuranose binding)
HGNC id	18259

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.63 kb     8 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017625 8 - 1209 NP_060095 - 313 - 2006 16531507 also called omentin1 major circulating isoform in human plasma plasma omentin 1 levels were inversely correlated with BMI, waist circumference, leptin levels, and insulin resistance omentin 1 gene expression were decreased with obesity and were highly correlated with each other in visceral adipose tissue higher plasma omentin 1 levels were detected in lean subjects and in women compared with men variant 2 - - - isoform 2 - - - 2006 16531507 also called omentin 2, gene expression were decreased with obesity and were highly correlated with each other in visceral adipose tissue

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Cardiovascular heart         Digestive intestine large intestine colon       stomach

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	small intestine

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , trimer

HOMOLOGY

interspecies

homolog to murine intelectin

Homologene

FAMILY

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	brush border membrane

basic FUNCTION	adipokine playing a role in the recognition of bacteria-specific components in the host
	adipokine expressed in omental adipose tissue in humans and may regulate insulin action
	adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease
	its loss may contribute to the development of insulin resistance and T2DM
	potent insulin-sensitizing adipokine, and serum omentin levels possibly play an important role in the pathogenesis of insulin resistance and diabetes
	adipocytokine with insulin-sensitizing effect
	plays an anti-inflammatory role by preventing the TNF1-induced COX2 expression in vascular endothelial cells
	anti-inflammatory in vascular endothelial cells
	may inhibit TNF-induced expression of adhesion molecules in endothelial cells via blocking ERK/NFKB1 pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	omentin inhibited TNF-activated signal pathway of NFKB1 by preventing NFKB1 inhibitory protein (NFKBIA) degradation and NFKB1/DNA binding activity
	ITLN1 inhibition of TNF-induced expression of VCAM1 and ICAM1 is mediated by its down-regulation of ERK/NFKB signaling pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   associated with increasing obesity and insulin resistance constitutional     --low   by insulin and glucose (explain the decreased omentin-1 levels observed in overweight women with PCOS (Tan 2008) constitutional     --low   decreases in the overweight and obese human subjects constitutional     --low   found in many chronic inflammatory diseases constitutional     --low   in patients with acute coronary syndrome (ACS) and stable angina pectoris compared with controls constitutional     --over   SERPINA12 and ITLN1 are up-regulated in large for gestational age infants at term

Susceptibility

to obesity with insulin resistance

Variant & Polymorphism SNP	single nucleotide missense polymorphism Val109Asp associated with type 2 diabetes mellitus or chronic inflammatory bowel diseases

Candidate gene	omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity
Marker
Therapy target
	System Type Disorder Pubmed diabete     may be a potential drug target against the obesity and/or type II diabetes-related vascular diseases

ANIMAL & CELL MODELS