SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| text
| co-localization with microtubules |
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localizes to mitochondria dependending on sequences in the C-terminal region  |
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upon EGF stimulation, spartin translocates from the cytoplasm to the plasma membrane and colocalizes with internalized EGF-Alexa |
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exists in a cytosolic pool that can be recruited to endosomes and to lipid droplets |
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localize to the endosomal membrane traffic compartment, suggesting that the long axons of the corticospinal tract may be especially vulnerable to endosomal dysfunction |
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localizes to mitochondria and this localization is dependent on sequences in the C-terminal region (mutant spartin containing the 1110delA mutation has lost mitochondrial localization) |
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colocalizes with IST1 at the midbody, and depletion of IST1 in cells by small interfering RNA significantly decreases the number of cells where spartin is present at midbodies |
| basic FUNCTION
| involved in microtubule interaction |
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may be involved in endocytosis, vesicle trafficking, or mitogenic activity |
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mono-ubiquitinated and functioning in degradation of the epidermal growth factor receptor (EGFR) involved in the intracellular trafficking of EGFR (Bakowska 2007) |
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involved in the intracellular trafficking of EGFR (Bakowska 2007) |
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inhibitor of BMP signalling in neuronal and non-neuronal cells (Tsang 2009) |
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acts as an adaptor for WWP1 and ITCH (Edwards 2009) |
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involved in diverse cellular functions, which may be of relevance to the complex phenotype seen in Troyer syndrome (Edwards 2009) |
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multifunctional protein and that may have a role in protein folding and turnover both in mitochondria and endoplasmic reticulum (Milewska 2009) |
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a role in the regulation of lipid droplets turnover |
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SPART is involved in many cellular processes and associates with several intracellular organelles, including mitochondria. |
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inhibits bone morphogenetic protein signaling by promoting endocytic degradation of BMP receptor wishful thinking |
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regulates synaptic growth and function |
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regulates both synaptic development and neuronal survival by controlling microtubule stability via the BMP-dFMRP-Futsch pathway |
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there is a critical level of spartin expression which must be maintained for proper cellular functions |
