SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria,outer
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton,microtubule
|
text
| co-localization with microtubules |
|
localizes to mitochondria dependending on sequences in the C-terminal region  |
|
upon EGF stimulation, spartin translocates from the cytoplasm to the plasma membrane and colocalizes with internalized EGF-Alexa  |
|
exists in a cytosolic pool that can be recruited to endosomes and to lipid droplets  |
|
localize to the endosomal membrane traffic compartment, suggesting that the long axons of the corticospinal tract may be especially vulnerable to endosomal dysfunction  |
|
localizes to mitochondria and this localization is dependent on sequences in the C-terminal region (mutant spartin containing the 1110delA mutation has lost mitochondrial localization)  |
|
colocalizes with IST1 at the midbody, and depletion of IST1 in cells by small interfering RNA significantly decreases the number of cells where spartin is present at midbodies |