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FLASH GENE
Symbol CDON contributors: mct - updated : 19-03-2015
HGNC name cell adhesion molecule-related/down-regulated by oncogenes
HGNC id 17104
Corresponding disease
HPE11 holoprosencephaly-11
Location 11q24.2      Physical location : 125.826.714 - 125.933.187
Synonym name
  • down-regulated by oncogenes
  • Synonym symbol(s) CDO, ORCAM, HPE11
    DNA
    TYPE functioning gene
    STRUCTURE 106.47 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 8051 - 1264 - -
    - - 8116 - 1287 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five fibronectin type-iii domains
  • six ig-like c2-type (immunoglobulin-like) domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cdon
    homolog to Drosophila Lk6
    homolog to C.elegans R166.5
    intraspecies paralog to BOC
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY adhesion , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • TBK1 partly co-localizes with CDON along cellular processes in puncta-like structures
  • basic FUNCTION
  • involved in myogenic differentiation
  • functions to activate myogenic bHLH factors via enhanced heterodimer formation, most likely by inducing hyperphosphorylation of E proteins
  • CDON and BOC encode cell surface Ig/fibronectin superfamily members linked to muscle differentiation
  • CDON and APPL1 are required for efficient AKT1 activation during myoblast differentiation
  • activates AKT1 through association with APPL1 during myoblast differentiation, and this complex likely mediates some of the promyogenic effect of cell-cell interaction
  • CDON and BOC have specific, selective roles in Shh signaling
  • GAS1, CDON, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube
  • GAS1 and CDON are coexpressed in muscle cells and form a complex in differentiating myoblasts
  • CDON functions as a component of multiprotein cell surface complexes to promote myogenesis
  • promyogenic CDON signaling is critical for KCNJ2 activities in the induction of myogenic differentiation
  • CDON, is likely important in initiating oligodendrocytes (OLGs) differentiation and axon myelination by promoting the formation of branched cellular processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • APPL1, an interacting partner of AKT1, forms complexes with CDON and BOC in differentiating myoblasts
  • CDON forms a complex with KCNJ2 during myogenic differentiation, and is required for the channel activity by enhancing the surface expression of KCNJ2 in the early stage of differentiation
  • a CDON-TBK1 complex is associated with AKT1 phosphorylation and early OLG differentiation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • important for full ABL1 kinase activity, and ABL1 is necessary for full activation of MAPK14, during myogenic differentiation
  • binds SHH with micromolar affinity and positively regulates Hh signaling
  • interactions between HH proteins and CDON are weakened at low pH
  • all mammalian HH proteins bind CDO and BOC in the same manner
  • CDON promotes neural crest migration by regulating CDH2 localization
  • is involved in cell contact-mediated promyogenic signals through activation of MAPK14 and AKT1
  • cell & other
    REGULATION
    Other regulated by cell-substratum adhesion
    ASSOCIATED DISORDERS
    corresponding disease(s) HPE11
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in lung, breast and ovarian tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking the Shh pathway regulator Cdo (also called Cdon) display HPE with strain-dependent penetrance and expressivity, implicating silent modifier genes as one cause of the variability (