Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDCA7 contributors: mct - updated : 07-12-2017
HGNC name cell division cycle associated 7
HGNC id 14628
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila CG13890
homolog to C.elegans R06F6.9
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • participating in MYC-mediated transformation
  • MYC-responsive gene that participates in neoplastic transformation
  • being a unique transcription regulator whose expression is activated by E2F1 as well as MYC
  • is a recently identified target of MYC-dependent transcriptional regulation
  • is an evolutionary conserved NOTCH1 target involved in hematopoietic stem cell (HSC) emergence
  • ZBTB24, HELLS, CDCA7 gene products are not involved in establishing or maintaining subtelomeric methylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • HELLS-CDCA7 complex possesses nucleosome remodeling activity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MYC target gene
  • direct transcriptional target of transcription factor E2F1
  • CDCA7 associates with MYC and this association is modulated in a phosphorylation-dependent manner
  • ZBTB24 can likely function as a transcription factor directly controlling CDCA7 expression
  • cell & other
    REGULATION
    induced by c.Myc
    ASSOCIATED DISORDERS
    corresponding disease(s) ICF3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS