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FLASH GENE

Symbol

CDCA3

contributors: npt/mct - updated : 28/10/2008

HGNC name	cell division cycle associated 3
HGNC id	14624

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to Drosophila CG13890
	homolog to C.elegans R06F6.9

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	mediates the destruction of mitosis-inhibitory kinase WEE1 via E3 ligase KITLG
	required for proper activation of CDC2/cyclin B and mitotic entry
	may trigger entry into mitosis by interfering with this kinase/phosphatase 'switch'

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

substrate of APC

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS