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FLASH GENE

Symbol

CDCA3

contributors: npt/mct - updated : 28/10/2008

HGNC name	cell division cycle associated 3
HGNC id	14624

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CDCA3 6 - 1170 28 268 - Yoshida (2005)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly Lymphoid/Immune lymph node       highly   thymus       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to Drosophila CG13890
	homolog to C.elegans R06F6.9

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	mediates the destruction of mitosis-inhibitory kinase WEE1 via E3 ligase KITLG
	required for proper activation of CDC2/cyclin B and mitotic entry
	may trigger entry into mitosis by interfering with this kinase/phosphatase 'switch'

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

substrate of APC

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS