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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CDH2

contributors: shn/pgu - updated : 19-11-2019

HGNC name	cadherin 2, type 1, N-cadherin (neuronal)
HGNC id	1759

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ACOGS , ARVC14

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in ductal carcinomas, decreased levels in primary tumors correlate with local recurrence and death in long-term follow-up of patients constitutional         of either CDH2 or LIN7C disrupts neural tube formation constitutional         loss of CDH2 alters the actin cytoskeleton, leading to a decrease in the cortical actin-binding protein, CTTN, which associates with KCNA5 channel and regulates its function in the heart tumoral     --low   by promoter methylation in colorectal cancer patients constitutional     --over   partially attenuated nucleus pulposus (NP) cell senescence, decreased ROS content and inhibited the activation of the NFKB1 pathway under the high glucose condition

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   is a potential therapeutic target to slow Diabetes-mediated disc nucleus pulposus (NP) degeneration

ANIMAL & CELL MODELS

	Homozygous N-cadherin mutant embryos die by Day 10 of gestation
	in adult mice loss of N-cadherin in osteolineage cells favors bone formation