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FLASH GENE
Symbol CATSPER2 contributors: mct - updated : 22-03-2019
HGNC name cation channel, sperm associated 2
HGNC id 18810
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Ca2+ ion selective pore domain
  • a cellular localization
  • six transmembrane segments
    • HOMOLOGY
    interspecies homolog to murine Catsper2 (67.7pc)
    Homologene
    FAMILY
    CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localized in sperm flagellum
    basic FUNCTION
  • involved in sperm cell motility
  • expressed during the meiotic or postmeiotic stages of spermatogenesis
  • having required roles in male fertility
  • CATSPER channel complex serves as a polymodal sensor for multiple chemical cues that assist sperm during their voyage across the female genital tract
  • CATSPER1, CATSPER2 are voltage-dependent calcium channels located in the plasma membrane of the sperm flagellum and is responsible for triggering hyperactive motility
    • CELLULAR PROCESS cell cycle,division,meiosis
    cell migration & motility
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • cation transport (voltage-gated ion channel)
  • spermatogenesis
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • molecular mechanism responsible for activation of CATSPER1, CATSPER2 by progesterone arises early in sperm development concurrently with the CATSPER channel itself
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DIS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in asthenoteratozoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Catsper2 -/- mice