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FLASH GENE

Symbol

CATSPER1

contributors: mct - updated : 22-03-2019

HGNC name	cation channel, sperm associated 1
HGNC id	17116

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NSMI

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         impairs the phase of motility of spermatozoa constitutional       loss of function loss of CATSPER1 function is sufficient to compromise fertilizing capacity of human spermatozoa

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction contraception   blocking CATSPER1 activity could be useful as a male contraceptive

ANIMAL & CELL MODELS

Catsper 1 knock-out mice leads male sterility: sperm motility is decreased markedly in CatSper-/- mice, and CatSper-/- sperm are unable to fertilize intact eggs