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FLASH GENE
Symbol CARHSP1 contributors: mct/npt/pgu - updated : 10-10-2009
HGNC name calcium regulated heat stable protein 1, 24kDa
HGNC id 17150
Location 16p13.2      Physical location : 8.946.801 - 8.962.863
Synonym name calcium-regulated heat-stable protein 1
Synonym symbol(s) CRHSP-24, CSDC1, MGC111446 , CRHSP24
DNA
TYPE functioning gene
STRUCTURE 16.06 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3029 - 147 - 2006 17081983
4 - 2727 - 147 - 2006 17081983
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary glandparotid  highly
Endocrinepancreas   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveacinar
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal RNA-binding region with all of the phosphorylation sites (four regulated sites of phosphorylation as serines 30, 32, 41, and 52)
  • a CSD (cold-shock) domain
  • RNA-binding motifs that flank the central cold shock domain
  • HOMOLOGY
    intraspecies paralog to CSDC2
    Homologene
    FAMILY
  • cold-shock domain (CSD) family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • cytoplasmic protein localizing to processing bodies and exosomes but not on translating mRNAs
  • basic FUNCTION
  • playing a role in calcium-mediated signal transduction
  • may play a role in acinar cell metabolism
  • major calcineurin regulated phosphoprotein in pancreatic acinar cells
  • cold-shock domain-containing protein
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • STYX
  • TNF mRNA stability enhancer required for effective TNF production
  • cell & other
    REGULATION
    Other regulated by diverse and physiologically relevant signaling pathways in acinar cells, including Ca2+, cAMP, and diacylglycerol
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS