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FLASH GENE
Symbol WFDC12 contributors: mct - updated : 20-06-2011
HGNC name WAP four-disulfide core domain 12
HGNC id 16115
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly Homo sapiens
 salivary gland   highly Homo sapiens
Reproductivemale systemprostate  highly
Respiratoryrespiratory tracttrachea  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
    • HOMOLOGY
    intraspecies homolog to elafin
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • protease inhibitor
  • antibacterial proteins inhibiting the growth of both Escherichia coli and Staphylococcus aureus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS