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FLASH GENE
Symbol WFDC12 contributors: mct - updated : 20-06-2011
HGNC name WAP four-disulfide core domain 12
HGNC id 16115
Location 20q13.12      Physical location : 43.752.066 - 43.753.106
Synonym name
  • whey acidic protein 2
  • chromosome 20 open reading frame 122
  • protease inhibitor WAP2
  • single WAP motif protein 2
    • Synonym symbol(s) WAP2, dJ211D12.4, C20orf122, UNQ544/PRO844, SWAM2,
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 1.04 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located located 52kb upstream of the gene encoding the protease inhibitor elafin (Pi3)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 774 - 111 - 2002 12206714
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly Homo sapiens
     salivary gland   highly Homo sapiens
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tracttrachea  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
    • HOMOLOGY
    intraspecies homolog to elafin
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • protease inhibitor
  • antibacterial proteins inhibiting the growth of both Escherichia coli and Staphylococcus aureus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS