Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

LRIG1

contributors: mct - updated : 08-01-2020

HGNC name	leucine-rich repeats and immunoglobulin-like domains 1
HGNC id	17360

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in various cancers tumoral     --low   in renal cell carcinoma tumoral     --over   destabilizes endogenous Met receptor in breast cancer cells and impairs their ability to respond to hepatocyte growth factor tumoral     --over   suppresses malignant glioma cell growth by attenuating EGFR activity tumoral     --low   in squamous cell carcinoma of the uterine cervix, with high LRIG2 expression identified women with a very poor prognosis tumoral     --over   in prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	prognostic biomarker in non-small cell lung cancer
Therapy target
	System Type Disorder Pubmed cancer brain   feedback negative attenuator of EGFR and could offer a novel therapeutic target to treat patients with malignant gliomas

ANIMAL & CELL MODELS

Lrig1-deficient mice display morphological changes in proximal dendrite arborization and defects in social interaction