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FLASH GENE

Symbol

ATPAF2

contributors: mct - updated : 10-11-2006

HGNC name	ATP synthase mitochondrial F1 complex assembly factor 2
HGNC id	18802

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a highly conserved acidic residue near the C terminus

HOMOLOGY

interspecies

ortholog to yeast S.cerevisiae,assembly of the F1 component of the mitochondrial ATPase

intraspecies

paralog to ATPAF1

Homologene

FAMILY

ATP12 family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	preventing the ATP factor for the F(1) component from forming non productive homooligomers during enzyme assembly
	with ATPAF1, are proteins required for the assembly of beta (F(1)-beta) and alpha (F(1)-alpha) subunits into the mitochondrial ATPase
	required for the F1 assembly, preserved in all eukaryotic lineages that are capable of ATP synthesis via oxidative phosphorylation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

drug

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to F1 beta subunits

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

C5MTND

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS