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FLASH GENE

Symbol

DNASE2B

contributors: - updated : 03-04-2006

HGNC name	deoxyribonuclease II beta
HGNC id	28875

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p31.1      Physical location : 84.864.214 - 84.880.691
Synonym name	DNase 2-like acid DNase
	endonuclease DLAD
Synonym symbol(s)	DLAD
EC.number	3.1.22.1

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head, opposite orientation
text	head to head with the urate oxidase
STRUCTURE	16.00 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed DLAD-V1 - - 1280 - 357 - Krieser variant 2 - - 1030 - 153 lung Krieser lock the first two exons

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth           salivary gland         Lymphoid/Immune lymph node         Reproductive male system prostate     lowly   male system testis     lowly Respiratory lung           respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal signal peptide
	conserved active site

HOMOLOGY

interspecies

homolog to rattus JC7131 deoxyribonuclease 2-like acid

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION

playing an important role for maintaining the purine nucleotide pool in the liver

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS