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FLASH GENE

Symbol

LNX1

contributors: mct - updated : 14-03-2012

HGNC name	ligand of numb-protein X 1
HGNC id	6657

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in 100p100 of gliomas including low- and high-grade ones constitutional     --low   could result in cell cycle arrest in G0/G1 phase through inhibition of CTNNB, MAPK, NFKB, MYC-dependent pathway and activation of TP53, TGFB-dependent pathway

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	might act as a diagnostic marker and a potential therapeutic target for glioma

ANIMAL & CELL MODELS