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FLASH GENE
Symbol LIMS2 contributors: mct - updated : 16-02-2011
HGNC name LIM and senescent cell antigen-like domains 2
HGNC id 16084
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five LIM domains (mediating protein-protein interactions)
    • HOMOLOGY
    intraspecies homolog to LIMS1
    Homologene
    FAMILY PINCH protein family
    CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text PINCH-2 localizes to both cell-ECM contact sites and the nucleus
    basic FUNCTION
  • playing important roles at cell-extracellular matrix (ECM) adhesion sites
  • regulating the PINCH-1-ILK interaction, cell shape change and migration
  • involved in the regulation of integrin-mediated cell adhesion
  • LIMS1, and LIMS2 share overlapping functions and operate dependently and independently of their subcellular localization
  • novel LIM domain-containing gene, may play an important role in testicular development/spermatogenesis
  • 5 LIM domain-only adaptor protein that function as key components of the integrin signaling pathway and play crucial roles in multiple cellular processes
  • essential roles in myocardial growth, maturation, remodeling, and function
  • regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling
    • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    zinc zn2+
    protein
  • binding to ILK
  • interacting with UNC-98
  • LIMS1 and LIMS2 interact, through their first LIM domain, with the integrin-linked kinase and thereby link integrins with several signal transduction pathways
    • cell & other
    REGULATION
    Other regulated by IGF2BP2 (regulates the expression of LIMS2 and TRIM54 proteins via direct binding to their mRNAs)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS