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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

LIMS2

contributors: mct - updated : 16-02-2011

HGNC name	LIM and senescent cell antigen-like domains 2
HGNC id	16084

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q14.3      Physical location : 128.395.996 - 128.439.360
Synonym name	integrin linked kinase-binding protein
	ILK-binding protein
	LIM-like protein 2
	particularly interesting new Cys-His protein 2
Synonym symbol(s)	PINCH-2, FLJ10044

DNA

TYPE	functioning gene
STRUCTURE	43.37 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001136037 11 - 2128 NP_001129509 - 363 - 2002 12167643 isoform 1 NM_001161403 10 - 2062 NP_001154875 - 341 - 2002 12167643 isoform 3 variant PINCH2T - - 963 isoform PINCH2T - 117 high expression levels in adult testis 2007 17435276 NM_001161404 10 - 2352 NP_001154876 - 336 - 2002 12167643 isoform 5 NM_017980 10 - 2173 NP_060450 - 365 - 2002 12167643 isoform 2

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Homo sapiens Reproductive female system external genitalia         female system breast mammary gland     Urinary kidney       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth myoepithelium     Muscular striatum cardiac myocardium   Homo sapiens Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

five LIM domains (mediating protein-protein interactions)

HOMOLOGY

intraspecies

homolog to LIMS1

Homologene

FAMILY

PINCH protein family

CATEGORY

adhesion , regulatory

SUBCELLULAR LOCALIZATION	plasma membrane,junction,adherens
	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	PINCH-2 localizes to both cell-ECM contact sites and the nucleus

basic FUNCTION	playing important roles at cell-extracellular matrix (ECM) adhesion sites
	regulating the PINCH-1-ILK interaction, cell shape change and migration
	involved in the regulation of integrin-mediated cell adhesion
	LIMS1, and LIMS2 share overlapping functions and operate dependently and independently of their subcellular localization
	novel LIM domain-containing gene, may play an important role in testicular development/spermatogenesis
	5 LIM domain-only adaptor protein that function as key components of the integrin signaling pathway and play crucial roles in multiple cellular processes
	essential roles in myocardial growth, maturation, remodeling, and function
	regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling

CELLULAR PROCESS

cell migration & motility

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule
	zinc zn2+

protein	binding to ILK
	interacting with UNC-98
	LIMS1 and LIMS2 interact, through their first LIM domain, with the integrin-linked kinase and thereby link integrins with several signal transduction pathways

cell & other

REGULATION

Other

regulated by IGF2BP2 (regulates the expression of LIMS2 and TRIM54 proteins via direct binding to their mRNAs)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS