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FLASH GENE
Symbol LIMS2 contributors: mct - updated : 16-02-2011
HGNC name LIM and senescent cell antigen-like domains 2
HGNC id 16084
Location 2q14.3      Physical location : 128.395.996 - 128.439.360
Synonym name
  • integrin linked kinase-binding protein
  • ILK-binding protein
  • LIM-like protein 2
  • particularly interesting new Cys-His protein 2
  • Synonym symbol(s) PINCH-2, FLJ10044
    DNA
    TYPE functioning gene
    STRUCTURE 43.37 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC150554 2q21.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene GYPC 2q14-q21 glycophorin C (Gerbich blood group) LOC339760 2q21.1 hypothetical LOC339760 BIN1 2q14 bridging integrator 1 LOC389029 2 LOC389029 LOC339761 2q21.1 similar to 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (Calcidiol 1-monooxygenase) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha) ERCC3 2q21 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) MAP3K2 2q14.3 mitogen-activated protein kinase kinase kinase 2 LOC389030 2 LOC389030 PROC 2q13-q14 protein C (inactivator of coagulation factors Va and VIIIa) FLJ10006 2q21.1 hypothetical protein FLJ10006 LOC389031 2 similar to myosin-VIIb MYO7B 2q21.1 myosin VIIB LIMS2 2q14.2 LIM and senescent cell antigen-like domains 2 GPR17 2q21 G protein-coupled receptor 17 MGC5391 2q21.1 hypothetical protein MGC5391 FLJ11294 2q21.1 hypothetical protein FLJ11294 POLR2D 2q21 polymerase (RNA) II (DNA directed) polypeptide D MGC4268 2q21 hypothetical protein MGC4268 SAP130 2q21.1 mSin3A-associated protein 130 UGCGL1 2q14.2 UDP-glucose ceramide glucosyltransferase-like 1 HS6ST1 2q21 heparan sulfate 6-O-sulfotransferase 1 LOC391432 2 similar to hypothetical protein LOC389032 2 LOC389032 LOC391433 2 similar to peptidyl-Pro cis trans isomerase LOC391434 2 similar to hypothetical protein DKFZp434P0316
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2128 - 363 - 2002 12167643
    isoform 1
    10 - 2062 - 341 - 2002 12167643
    isoform 3
    - - 963 - 117 high expression levels in adult testis 2007 17435276
    10 - 2352 - 336 - 2002 12167643
    isoform 5
    10 - 2173 - 365 - 2002 12167643
    isoform 2
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    Reproductivefemale systemexternal genitalia   
     female systembreastmammary gland  
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothmyoepithelium  
    Muscularstriatumcardiacmyocardium  Homo sapiens
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five LIM domains (mediating protein-protein interactions)
  • HOMOLOGY
    intraspecies homolog to LIMS1
    Homologene
    FAMILY PINCH protein family
    CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text PINCH-2 localizes to both cell-ECM contact sites and the nucleus
    basic FUNCTION
  • playing important roles at cell-extracellular matrix (ECM) adhesion sites
  • regulating the PINCH-1-ILK interaction, cell shape change and migration
  • involved in the regulation of integrin-mediated cell adhesion
  • LIMS1, and LIMS2 share overlapping functions and operate dependently and independently of their subcellular localization
  • novel LIM domain-containing gene, may play an important role in testicular development/spermatogenesis
  • 5 LIM domain-only adaptor protein that function as key components of the integrin signaling pathway and play crucial roles in multiple cellular processes
  • essential roles in myocardial growth, maturation, remodeling, and function
  • regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    zinc zn2+
    protein
  • binding to ILK
  • interacting with UNC-98
  • LIMS1 and LIMS2 interact, through their first LIM domain, with the integrin-linked kinase and thereby link integrins with several signal transduction pathways
  • cell & other
    REGULATION
    Other regulated by IGF2BP2 (regulates the expression of LIMS2 and TRIM54 proteins via direct binding to their mRNAs)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS