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FLASH GENE

Symbol

PPP1R14B

contributors: mct - updated : 10-07-2014

HGNC name	protein phosphatase 1, regulatory (inhibitor) subunit 14B
HGNC id	9057

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head, opposite orientation
STRUCTURE	2.46 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
text structure	no TATA, no CCAAT
	housekeeping promoter

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

4.4 kb upstream of PLCB3 with the 5'ends facing each other

RNA

TRANSCRIPTS	type	messenger

text	PHI-1 and a larger PHI-2 (Eto)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138689 4 - 1038 NP_619634 - 147 - 1999 10606530

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Endocrine neuroendocrine pituitary     highly Lymphoid/Immune lymph node       highly Respiratory lung       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	participating in regulatory events at the trailing edge of migrating cells and modulating retraction of endothelial and epithelial cells
	myosin phosphatase (MP) inhibitory subunit

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

inhibitor of PPP1CA

cell & other

REGULATION

activated by

phosphorylation by PKC on THr57 and a ser

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS