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FLASH GENE
Symbol TNNT3 contributors: mct - updated : 12-04-2014
HGNC name troponin T type 3 (skeletal, fast)
HGNC id 11950
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth  specific Homo sapiens
Muscularstriatumcardiac specific Homo sapiens
Muscularstriatumskeletal specific Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in fast skeletal muscles
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • both a nuclear localization signal
  • and a DNA-binding domain, which may mediate nuclear/nucleolar signaling and muscle cell apoptosis
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Tnnt3
    homolog to C.elegans Y49F6B.2
    Homologene
    FAMILY
  • troponin T family
    • CATEGORY motor/contractile , regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in the attachment of the complex to tropomyosin and troponin I
  • involved in the regulation of striated muscle contraction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , locomotion
    text fast skeletal muscles development
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the troponin complex forming the calcium-sensitive molecular switch that regulates striated muscle contraction in response to modifications in intracellular concentration
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to tropomyosin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMCD2B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • aberrant TNNT3 represents a biological marker of muscle phenotype severity and disease progressionin FSHMD1A
    • Therapy target
    ANIMAL & CELL MODELS