Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

TNNT3

contributors: mct - updated : 12-04-2014

HGNC name	troponin T type 3 (skeletal, fast)
HGNC id	11950

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	64 isoforms generated by a combinatorial splicing involving exons 4-8

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006757 16 - 1217 NP_006748 30.5 258 - 1999 1036420 NM_001042782 15 - 1193 NP_001036247 29.6 250 - 1999 1036420 NM_001042781 16 - 1211 NP_001036246 30.2 256 - 1999 1036420 NM_001042780 15 - 1193 NP_001036245 29.6 250 - 1999 1036420

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth     specific Homo sapiens Muscular striatum cardiac   specific Homo sapiens Muscular striatum skeletal   specific Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	highly in fast skeletal muscles

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	both a nuclear localization signal
	and a DNA-binding domain, which may mediate nuclear/nucleolar signaling and muscle cell apoptosis

conjugated

PhosphoP

HOMOLOGY

interspecies	ortholog to murine Tnnt3
	homolog to C.elegans Y49F6B.2

Homologene

FAMILY

troponin T family

CATEGORY

motor/contractile , regulatory , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	involved in the attachment of the complex to tropomyosin and troponin I
	involved in the regulation of striated muscle contraction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , locomotion

text	fast skeletal muscles development

PATHWAY

metabolism

signaling

a component

constituent of the troponin complex forming the calcium-sensitive molecular switch that regulates striated muscle contraction in response to modifications in intracellular concentration

INTERACTION

DNA

RNA

small molecule

protein

binding to tropomyosin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AMCD2B

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	aberrant TNNT3 represents a biological marker of muscle phenotype severity and disease progressionin FSHMD1A
Therapy target

ANIMAL & CELL MODELS