| basic FUNCTION
| functions as an essential scaffolding protein to coordinate the assembly of Raf-MEK-ERK complexes |
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promoting MEK and RAF phosphorylation and activity through assembly of an activated signaling complex |
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positive modulator of ras-MAP kinase signaling |
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molecular scaffold kinase suppressor of Ras 1 (KSR1) regulating adipogenesis |
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protecting intestinal epithelium from TNF-alpha-induced apoptosis |
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mitogen-activated protein (MAP) kinase scaffold that enhances the activation of the MAP kinase extracellular signal-regulated kinase (ERK)  |
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required for efficient NK-mediated cytolysis and polarization of cytolytic granules |
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recruited to the immunological synapse during T-cell activation and membrane recruitment of KSR1 is required for recruitment of active ERK to the synapse |
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plays a central role in determining the sensitivity of T-cell responses and is thus well positioned as a key control point |
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required for maximal ERK activation induced by growth factors and by some cytotoxic agents |
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playing a specific role in the cellular response to DNA interstrand cross-links |
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likely control point used to fine-tune T-cell responses during T-cell activation and differentiation, suggesting KSR1 as a key regulator of T-cell function and plasticity |
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despite a requirement for KSR1 for full ERK activation in thymocytes, full and efficient ERK activation is not essential for the majority of thymocyte selection events |
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functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MAP2K1 |
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KSR1 is a bona fide kinase whose activity is required to cooperate with RAF for the activation of MEK |
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may potentially phosphorylate MEK and this phosphorylation facilitates RAF1 phosphorylation of the activation loop |
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molecular scaffold of the RAF1/MEK/extracellular signal-regulated kinase (ERK) cascade that enhances oncogenic RAS signaling |
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KSR1-dependent control of PPARGC1A- and ESRRA-dependent pathways that are necessary and sufficient for signaling by oncogenic HRAS to regulate metabolism and anchorage-independent growth |
