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FLASH GENE

Symbol

KCNAB2

contributors: shn - updated : 28-02-2024

HGNC name	potassium voltage-gated channel, shaker-related subfamily, beta member 2
HGNC id	6229

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL1P36

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function can contribute to the Brugada electrocardiographic pattern

Susceptibility

to epilepsia

Variant & Polymorphism

Candidate gene	for seizures in del1p36 syndrome, primary gene or modifier
Marker	can be exploited as a predictive biomarker for evaluating prognosis in Lung adenocarcinoma (LUAD)
Therapy target
	System Type Disorder Pubmed tumor     potential new target and pharmacological candidate to be considered in the development of clinical therapeutics for acromegaly cancer lung   possible immunotherapeutic target in Lung adenocarcinoma (LUAD)

ANIMAL & CELL MODELS

	Kvbeta2-null mice have reduced life spans, occasional seizures, and cold swim-induced tremors (
	mice deleted for KCNAB2 leads to deficits in associative learning and memory, a reduction in the slow afterhyperpolarization following a burst of action potentials and a concomitant increase in neuronal excitability in projection neurons in the lateral nucleus of the amygdala (