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FLASH GENE
Symbol RAB34 contributors: mct - updated : 02-10-2012
HGNC name RAB34, member RAS oncogene family
HGNC id 16519
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
intraspecies homolog to RAB36
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
    • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in vesicular traffic
  • Golgi-localized RAB34 has been implicated in repositioning lysosomes and activation of macropinocytosis
  • novel member of the secretory pathway acting at the Golgi
  • RAB34 and its effector UNC13B constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia
  • Golgi-associated Rab protein that regulates lysosomal positioning through interaction with RILP
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
  • UNC13B serves as an effector of RAB34, mediating lysosome-Golgi trafficking
  • UNC13B and RAB34 interact at the Golgi via the munc13 homology domain 2 (MHD2)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS