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FLASH GENE
Symbol RAB34 contributors: mct - updated : 02-10-2012
HGNC name RAB34, member RAS oncogene family
HGNC id 16519
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Endocrinepancreas   highly
Nervousbrain    
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
intraspecies homolog to RAB36
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
    • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in vesicular traffic
  • Golgi-localized RAB34 has been implicated in repositioning lysosomes and activation of macropinocytosis
  • novel member of the secretory pathway acting at the Golgi
  • RAB34 and its effector UNC13B constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia
  • Golgi-associated Rab protein that regulates lysosomal positioning through interaction with RILP
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
  • UNC13B serves as an effector of RAB34, mediating lysosome-Golgi trafficking
  • UNC13B and RAB34 interact at the Golgi via the munc13 homology domain 2 (MHD2)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS