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FLASH GENE
Symbol RAB33B contributors: mct - updated : 26-08-2013
HGNC name RAB33B, member RAS oncogene family
HGNC id 16075
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
interspecies homolog to murine Rab33b
intraspecies homolog to RAB33A
Homologene
FAMILY
  • small GTPase superfamily
  • RAS oncogene family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text associated with the golgi apparatus (medial Golgi cisternae)
    basic FUNCTION
  • involved in vesicular traffic
  • playing a role in intra-Golgi transport
  • modulates autophagosome formation through interaction with ATG16L1
  • RAB33B/RAB6A regulated intra-Golgi retrograde trafficking pathway must coexist with other Golgi trafficking pathways
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
  • RAB33B (and RAB33A) specifically interacts with ATG16L1, an essential factor in isolation membrane formation, in a guanosine triphosphate-dependent manner
  • RAB33B and RAB6A act to coordinate a major intra-Golgi retrograde trafficking pathway
  • target substrate of TBC1D25 and is involved in the fusion between autophagosomes and lysosomes, the same as TBC1D25
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SMCD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS