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FLASH GENE
Symbol RAB25 contributors: mct - updated : 21-01-2015
HGNC name RAB25, member RAS oncogene family
HGNC id 18238
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
interspecies ortholog to murine Rab25
homolog to Drosophila CG7646
homolog to C.elegans ncs-2
Homologene
FAMILY
  • RAS superfamily
  • RAB subfamily
    • CATEGORY protooncogene , signaling , receptor membrane G , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • regulating selectively the apical recycling and/or transcytotic pathway
  • involved in apical vesicle trafficking
  • increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress
  • RAB11A, and RAB25 promote cell migration by regulating vesicular transport and recycling of surface receptors
  • acts predominantly in the small-scale fast recycling within the tips of the cell
  • controls intestinal cell polarity through the regulation of gene expression
  • can promote bladder metastasis through induction of epithelial-mesenchymal transition process and activation of AKT1/GSK3B/SNAI1 signaling pathway
  • epithelial-specific, and heavily implicated in ovarian cancer development, it independently appears to act as a tumour suppressor in the context of a distinct subset of carcinomas
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • GRHL2 regulates epithelial morphogenesis through transcriptional up-regulation of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at TJs
  • associates with OPTN and can recruit this effector protein to endosomal membranes
  • GRHL2/OVOL2 network controlling CLDN4 and RAB25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in bladder cancers compared with normal bladder tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS