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FLASH GENE
Symbol RAB25 contributors: mct - updated : 21-01-2015
HGNC name RAB25, member RAS oncogene family
HGNC id 18238
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
interspecies ortholog to murine Rab25
homolog to Drosophila CG7646
homolog to C.elegans ncs-2
Homologene
FAMILY
  • RAS superfamily
  • RAB subfamily
    • CATEGORY protooncogene , signaling , receptor membrane G , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • regulating selectively the apical recycling and/or transcytotic pathway
  • involved in apical vesicle trafficking
  • increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress
  • RAB11A, and RAB25 promote cell migration by regulating vesicular transport and recycling of surface receptors
  • acts predominantly in the small-scale fast recycling within the tips of the cell
  • controls intestinal cell polarity through the regulation of gene expression
  • can promote bladder metastasis through induction of epithelial-mesenchymal transition process and activation of AKT1/GSK3B/SNAI1 signaling pathway
  • epithelial-specific, and heavily implicated in ovarian cancer development, it independently appears to act as a tumour suppressor in the context of a distinct subset of carcinomas
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • GRHL2 regulates epithelial morphogenesis through transcriptional up-regulation of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at TJs
  • associates with OPTN and can recruit this effector protein to endosomal membranes
  • GRHL2/OVOL2 network controlling CLDN4 and RAB25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in bladder cancers compared with normal bladder tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS