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FLASH GENE
Symbol AGFG2 contributors: np/ - updated : 13-11-2007
HGNC name ArfGAP with FG repeats 2
HGNC id 5177
Location 7q22.1      Physical location : 100.136.833 - 100.165.842
Synonym name
  • HIV-1 Rev binding protein-like
  • Rev/Rex activation domain binding protein-related
  • nucleoporin
  • arf-GAP domain and FG repeats-containing protein 2
  • Synonym symbol(s) RABR, HRBL
    DNA
    TYPE functioning gene
    STRUCTURE 29.01 kb     12 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text alternatively spliced variants, not fully characterized, have been described
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4821 48 481 - PMID: 9303539
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   moderately
    Hearing/Equilibriumear   highly
    Lymphoid/Immunespleen   highly
    Nervousbrain    
     nerve   highly
    Reproductivefemale systemovary  moderately
     female systemplacenta  moderately
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion moderately in blood and lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an Arf-GAP C4-type zinc finger domain
  • several phe-gly (FG) motifs (characteristic of nucleoporin-like proteins)
  • four asn-pro-phe (NPF) motifs located in the C terminal half
  • HOMOLOGY
    interspecies homolog to Drosophila drongo
    homolog to rattus Hrbl (84 pc)
    homolog to murine Hrbl (83.2 pc)
    Homologene
    FAMILY
  • HIV-1 Rev binding protein (HRB) family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in the regulation of GTPase
  • playing a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs
  • playing a role as cellular cofactor of the human immunodeficiency virus Rev protein (pathogenic invasion)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to EH domain of EPS15
  • interacting with EPS15R
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS