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FLASH GENE
Symbol PHF21A contributors: mct - updated : 26-06-2012
HGNC name PHD finger protein 21A
HGNC id 24156
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two chromo-domains
  • a PHD zinc-finger domain
  • C-terminal PHD zinc-finger domain capable of binding directly to each of five other components of BHC, and of organizing BHC mediating transcriptional repression
    • HOMOLOGY
    interspecies homolog to Drosophila CG3911
    homolog to C.elegans ZK1098.5
    Homologene
    FAMILY snf2/rad54 helicase family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in repression of bithorax complex (bxc) genes by binding to a portion of hunchback (HB) protein
  • playing a role in polycomb group (pcg) repression of HOX genes
  • playing a role in the deacetylation of histones
  • mediating REST-dependent transcriptional repression of neuron-specific genes in non-neuronal cells
  • scaffold protein in BHC in neuronal as well as non-neuronal cells and may be playing a role in spermatogenesis
  • inhibits RCOR1/PHF21A-mediated demethylation and may therefore confer negative regulation
  • PHF21A and KDM1A depend reciprocally on one another to associate with chromatin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • component of the BRAF-histone deacetylase complex (BHC)BRAF/HDAC complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to HDAC1 and HDAC2
  • PHD finger of PHF21A binds unmethylated H3K4 (H3K4me0), and this interaction is specifically abrogated by methylation of H3K4
  • mediate REST repression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Bhc80-deficient mice showed no developmental defect in the neuronal and non-neuronal tissues, but is indispensable for the survival of neonatal pups