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FLASH GENE

Symbol

PHF21A

contributors: mct - updated : 26-06-2012

HGNC name	PHD finger protein 21A
HGNC id	24156

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly   pancreas         Nervous brain         Homo sapiens Reproductive female system ovary     highly Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	predominant expression of detected in the developing CNS at early stagesb

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two chromo-domains
	a PHD zinc-finger domain
	C-terminal PHD zinc-finger domain capable of binding directly to each of five other components of BHC, and of organizing BHC mediating transcriptional repression

HOMOLOGY

interspecies	homolog to Drosophila CG3911
	homolog to C.elegans ZK1098.5

Homologene

FAMILY

snf2/rad54 helicase family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in repression of bithorax complex (bxc) genes by binding to a portion of hunchback (HB) protein
	playing a role in polycomb group (pcg) repression of HOX genes
	playing a role in the deacetylation of histones
	mediating REST-dependent transcriptional repression of neuron-specific genes in non-neuronal cells
	scaffold protein in BHC in neuronal as well as non-neuronal cells and may be playing a role in spermatogenesis
	inhibits RCOR1/PHF21A-mediated demethylation and may therefore confer negative regulation
	PHF21A and KDM1A depend reciprocally on one another to associate with chromatin

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

component of the BRAF-histone deacetylase complex (BHC)BRAF/HDAC complex

INTERACTION

DNA

RNA

small molecule

protein	binding to HDAC1 and HDAC2
	PHD finger of PHF21A binds unmethylated H3K4 (H3K4me0), and this interaction is specifically abrogated by methylation of H3K4
	mediate REST repression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Bhc80-deficient mice showed no developmental defect in the neuronal and non-neuronal tissues, but is indispensable for the survival of neonatal pups