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FLASH GENE
Symbol THOP1 contributors: - updated : 13-05-2006
HGNC name thimet oligopeptidase 1
HGNC id 11793
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus metalloendopeptidase 24.15
Homologene
FAMILY peptidase m3 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • involved in antigen presentation via MHC class 1
  • beta secretase, catalyzing the degradation of somatostatin peptide from APP
  • involved in the metabolism of neuropeptides under 20 amino acid residues long
  • able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments
  • play a major role in degrading proteasome products
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 1 zinc ion per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS