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FLASH GENE

Symbol

THOP1

contributors: - updated : 13-05-2006

HGNC name	thimet oligopeptidase 1
HGNC id	11793

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Lymphoid/Immune tonsils       highly Nervous brain         Reproductive female system ovary     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

interspecies

homolog to rattus metalloendopeptidase 24.15

Homologene

FAMILY

peptidase m3 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	involved in antigen presentation via MHC class 1
	beta secretase, catalyzing the degradation of somatostatin peptide from APP
	involved in the metabolism of neuropeptides under 20 amino acid residues long
	able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments
	play a major role in degrading proteasome products

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 1 zinc ion per subunit

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS