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FLASH GENE
Symbol AP3B2 contributors: mct/npt - updated : 26-01-2017
HGNC name adaptor-related protein complex 3, beta 2 subunit
HGNC id 567
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
mono polymer heteromer , tetramer
HOMOLOGY
interspecies homolog to murine Ap3B2
homolog to Drosophila rb
homolog to C.elegans R11A5.1b
Homologene
FAMILY
  • adaptor complexes large subunits family
    • CATEGORY adaptor , antigen , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • secretory vesicle membrane
  • Golgi region and peripheral structures
    • basic FUNCTION
  • acting in protein transport between neuron cell body and axon
  • facilitating the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • vesicle transport (post Golgi)
  • secretory vesicle
    • PATHWAY
    metabolism
    signaling
    a component
  • component of the AP-3 complex composed of two large chains (delta and beta 3), a medium chain (MU3) and a small chain (sigma 3)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPB41L2 binds to the AP3B2 protein, which is involved in neuronal membrane trafficking, and promotes neurite extension in an AP3B2-dependent manner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE48
    Susceptibility
  • to severe chronic periodontitis
    • Variant & Polymorphism SNP rs11631963-rs11637433 are associated to severe chronic periodontitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS