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FLASH GENE
Symbol AP3B2 contributors: mct/npt - updated : 26-01-2017
HGNC name adaptor-related protein complex 3, beta 2 subunit
HGNC id 567
DNA
TYPE functioning gene
STRUCTURE 50.83 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 3771 119 1082 - 2007 17453999
- - 1171 - 145 relatively high in brain and testis 2007 17453999
27 - 3828 - 1101 - 2007 17453999
25 - 3675 - 1050 - 2007 17453999
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum  
 braindiencephalonhypothalamus  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
mono polymer heteromer , tetramer
HOMOLOGY
interspecies homolog to murine Ap3B2
homolog to Drosophila rb
homolog to C.elegans R11A5.1b
Homologene
FAMILY
  • adaptor complexes large subunits family
  • CATEGORY adaptor , antigen , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • secretory vesicle membrane
  • Golgi region and peripheral structures
  • basic FUNCTION
  • acting in protein transport between neuron cell body and axon
  • facilitating the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • vesicle transport (post Golgi)
  • secretory vesicle
  • PATHWAY
    metabolism
    signaling
    a component
  • component of the AP-3 complex composed of two large chains (delta and beta 3), a medium chain (MU3) and a small chain (sigma 3)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPB41L2 binds to the AP3B2 protein, which is involved in neuronal membrane trafficking, and promotes neurite extension in an AP3B2-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE48
    Susceptibility
  • to severe chronic periodontitis
  • Variant & Polymorphism SNP rs11631963-rs11637433 are associated to severe chronic periodontitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS