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FLASH GENE
Symbol FUT3 contributors: mct/ - updated : 11-06-2020
HGNC name fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
HGNC id 4014
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • amino acid residue near the amino terminus of the catalytic domain contributing to the acceptor substrate specificity
  • a Lys/Arg residue required for catalysis
    • HOMOLOGY
    interspecies homolog to C.elegans WO3G11.3
    Homologene
    FAMILY
  • glycosyltransferase family 10
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type 2 membrane protein
    basic FUNCTION
  • may be involved in blood group lewis determination
  • FUT3 is the key enzyme driving sialyl Lewis A (sLe(a)) biosynthesis in human intestinal epithelial cells (IECs)
  • selection of mutualistic microorganisms of the intestinal microbiota is controlled by the FUT2 and FUT3 genes that encode fucosyltransferases, enzymes responsible for the synthesis of fucosylated glycan structures of mucins and milk oligosaccharides
  • FUT3/FUT6 has an essential role in cancer cell adhesion to endothelial cells by upregulation of sialyl Lewis antigens and also by enhancement of cancer cell migration through TGFB1-mediated EMT
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LE
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    altered expression of fucosylation pathway gene(FUT3), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)
    Susceptibility to intestinal-type gastric cancer
    Variant & Polymorphism other
  • variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 associated with intestinal-type gastric cancer
    • Candidate gene
    Marker
  • could be useful to predict respectively breast cancer susceptibility
  • is a predictive factor for poor overall survival and recurrence free survival in patients with Clear Cell Renal Cell Carcinoma
    • Therapy target
    ANIMAL & CELL MODELS