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FLASH GENE
Symbol NAV1 contributors: mct - updated : 19-09-2017
HGNC name neuron navigator 1
HGNC id 15989
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text developing brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lacking the CH domain present in the other NAV
  • several coiled-coil domains
  • conserved AAA motif
    • HOMOLOGY
    interspecies homolog to C.elegans Unc53
    Homologene
    FAMILY
  • Nav/unc-53 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • potential role of NAV1 in mediating Netrin-1-induced directional migration
  • is important for neurite outgrowth
  • NAV1 regulates TRIO-mediated RAC1 activation and neurite outgrowth
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts and colocalizes with TRIO, a Rho guanine nucleotide exchange factor that enables neurite outgrowth by activating the Rho GTPases RAC1 and RHOG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS