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FLASH GENE
Symbol NAV1 contributors: mct - updated : 19-09-2017
HGNC name neuron navigator 1
HGNC id 15989
Location 1q32.1      Physical location : 201.617.449 - 201.796.102
Synonym name
  • pore membrane and/or filament interacting like protein 3
  • Unc-53 homolog 1
    • Synonym symbol(s) FLJ12560, FLJ14203, KIAA1151, MGC14961, POMFIL3, steerin-1, DKFZp781D0314, KIAA1213, unc53H1
    DNA
    TYPE functioning gene
    STRUCTURE 178.65 kb     30 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 13029 202 1877 - 2014 25065758
    27 - 11689 - 1483 - 2014 25065758
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text developing brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lacking the CH domain present in the other NAV
  • several coiled-coil domains
  • conserved AAA motif
    • HOMOLOGY
    interspecies homolog to C.elegans Unc53
    Homologene
    FAMILY
  • Nav/unc-53 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • potential role of NAV1 in mediating Netrin-1-induced directional migration
  • is important for neurite outgrowth
  • NAV1 regulates TRIO-mediated RAC1 activation and neurite outgrowth
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts and colocalizes with TRIO, a Rho guanine nucleotide exchange factor that enables neurite outgrowth by activating the Rho GTPases RAC1 and RHOG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS