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FLASH GENE
Symbol SLC39A4 contributors: snh - updated : 23-02-2009
HGNC name solute carrier family 39 (zinc transporter), member 4
HGNC id 17129
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight transmembrane domains organized in two blocks of three and five segments separated by a variable intracytoplasmic metal binding site
  • a cytoplasmic histidine-rich domain essential for ubiquitin-dependent degradation of ZIP4 and protection against zinc toxicity
  • an ectodomain which is cleaved and internalized during periods of zinc deficiency
    • HOMOLOGY
    interspecies ortholog to Slc39a4, mus musculus
    ortholog to Slc39a4, Rattus norvegicus
    ortholog to SLC39A4, Pan troglodytes
    ortholog to slc39a4, Danio rerio
    Homologene
    FAMILY
  • zinc/iron-regulated transporter-like protein (ZIP) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • involved in intestinal absorption and homeostasis of zinc
  • zinc importer required for zinc uptake in enterocytes and other cell types
  • playing an important role in maintaining the cellular zinc level by uptaking dietary zinc into intestinal epithelial cells and releasing zinc from vesicular compartments
  • in mice ZIP4 is essential for survival of the early embryo,and heterozygosity hypersensitizes mice to the effects of zinc deficiency
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text zinc specific transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AEZ
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly higher in pancreatic cancer cells than pancreatic ductal epithelium
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    targeted to control pancreatic cancer growth
    ANIMAL & CELL MODELS
    bovine hereditary zinc deficiency has a clinical presentation similar to acrodermatitis enteropathica in humans