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FLASH GENE

Symbol

SLC39A4

contributors: snh - updated : 23-02-2009

HGNC name	solute carrier family 39 (zinc transporter), member 4
HGNC id	17129

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine duodenum   highly   intestine small intestine ileum   highly   intestine small intestine     moderately   intestine small intestine jejunum   highly   intestine large intestine colon   highly   intestine large intestine caecum   highly   stomach       lowly Endocrine pancreas islet of Langerhans     predominantly Respiratory lung       lowly

cells

System Cell Pubmed Species Stage Rna symbol Digestive enterocyte

cell lineage
cell lines	ZIP4 mRNA expression is significantly higher in human pancreatic cancer cells than normal pancreatic ductal epithelial cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	eight transmembrane domains organized in two blocks of three and five segments separated by a variable intracytoplasmic metal binding site
	a cytoplasmic histidine-rich domain essential for ubiquitin-dependent degradation of ZIP4 and protection against zinc toxicity
	an ectodomain which is cleaved and internalized during periods of zinc deficiency

HOMOLOGY

interspecies	ortholog to Slc39a4, mus musculus
	ortholog to Slc39a4, Rattus norvegicus
	ortholog to SLC39A4, Pan troglodytes
	ortholog to slc39a4, Danio rerio

Homologene

FAMILY

zinc/iron-regulated transporter-like protein (ZIP) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome

basic FUNCTION	involved in intestinal absorption and homeostasis of zinc
	zinc importer required for zinc uptake in enterocytes and other cell types
	playing an important role in maintaining the cellular zinc level by uptaking dietary zinc into intestinal epithelial cells and releasing zinc from vesicular compartments
	in mice ZIP4 is essential for survival of the early embryo,and heterozygosity hypersensitizes mice to the effects of zinc deficiency

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

active transport

text	zinc specific transporter

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AEZ

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly higher in pancreatic cancer cells than pancreatic ductal epithelium

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive pancreas targeted to control pancreatic cancer growth

ANIMAL & CELL MODELS

bovine hereditary zinc deficiency has a clinical presentation similar to acrodermatitis enteropathica in humans