Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | SLC39A4 | contributors: snh - updated : 23-02-2009 |
HGNC name | solute carrier family 39 (zinc transporter), member 4 |
HGNC id | 17129 |
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Corresponding disease |
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Location | 8q24.3 Physical location : 145.637.798 - 145.642.273 | ||
Synonym name | |||
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Synonym symbol(s) | ZIP4, AEZ, FLJ20327, MGC74741 |
DNA |
TYPE | functioning gene |
STRUCTURE | 4.48 kb 12 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
Map | cen - D8S1836 - D8S373 - SLC39A4 - qter |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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cells |
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cell lineage
cell lines
| ZIP4 mRNA expression is significantly higher in human pancreatic cancer cells than normal pancreatic ductal epithelial cells | fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | ortholog to Slc39a4, mus musculus |
ortholog to Slc39a4, Rattus norvegicus | |
ortholog to SLC39A4, Pan troglodytes | |
ortholog to slc39a4, Danio rerio |
Homologene |
FAMILY |
CATEGORY | transport carrier |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,organelle,membrane | |
intracellular,cytoplasm,organelle,endosome |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | active transport |
text | zinc specific transporter |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | AEZ |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |
bovine hereditary zinc deficiency has a clinical presentation similar to acrodermatitis enteropathica in humans |